GeneBy Jessica Berman
Laptop Battery Scientists say they've developed a highly effective therapy to correct a defect in the gene that's responsible for the so-called "bubble-boy" disease.If you would like to receive late breaking news on health issues covered by AXcess News then you need to subscribe.
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Microsoft April 4, 2005 (AXcess News) Washington - Scientists say they've developed a highly effective therapy to correct a defect in the gene that's responsible for the so-called "bubble-boy" disease. They say it's likely the technique would be effective in treating a host of other disorders, including AIDS.
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Laptop Computers The promise of curing disease through gene therapy has remained elusive because researchers have yet to find a way to replace healthy genes with diseased ones.That was demonstrated in the case of three little boys in France who suffered from SCID or bubble-boy disease, a rare disorder in which patients suffer from a severely impaired immune system that usually results in death from infection. Researchers tried to replace the faulty gene responsible for SCID by attaching it to a virus. But the virus triggered a negative immune response, and the boys developed leukemia.
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Laptop Computer Since then, scientists have been working to develop an entirely different genetic delivery mechanism using so-called zinc fingers, which occur naturally inside the nucleus of each cell and bind to DNA, turning genes on and off. It's this genetic expression that determines whether someone develops a particular disease. Experts say zinc fingers are easily engineered to carry correct genetic information inside the cell.
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Desktop Computer In a study reported this week in Nature, scientists at Sangamo BioSciences in California report, using altered zinc fingers to permanently correct 20 percent of genes they studied that are responsible for SCID. While that doesn't sound like a huge percentage, it's very encouraging by scientific standards.
Notebooks Michael Holmes, who headed the study, says "what makes this an improvement is that we're actually correcting the gene that's mutated. We're not adding extra or foreign sequence to the cell. What our technology does is we go in and actually repair the gene that's mutated."Edward Landphair is Sangamo's president. "The technology is very powerful and very general and allows us to target any gene that we want in the genome and the approach that we're taking is targeting genes where there's a mutation, or mistake in that gene, that leads to a specific disease," he says.
Lenovo But scientists say zinc fingers are designed to treat diseases that are caused by a single, defective gene, such as sickle cell anemia.
Hard Drive Mr. Landphair says researchers are moving ahead with studies that use zinc fingers as a treatment for AIDS. "Specifically, going after a gene that allows the HIV virus to get into cells of the immune system. And by blocking or disrupting the gene that makes that receptor, we hope to protect cells of the immune system from HIV infection. And that's a program we're working to get into the clinic in the next 12 to 18 months," he says.
Travelstar Mr. Landphair says other studies are also looking at the use of zinc finger gene therapy in the treatment of some cardiovascular diseases and diabetic neuropathy.Source: Voice of America
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