Study: No effects of type II diabetes on aggressiveness of prostate cancer; long-term survival worse

October 17, 2005 keyboard

6 Predict Type II Diabetes In a study published in the July 18, 2001 issue of the Journal of the American Medical Association, a group from the famous Women's Health Study was evaluated to ascertain what risk factors could predict future development of Type II diabetes (Pradhan et al. 2001). 6 ( 6) were significantly higher among those who subsequently developed diabetes compared to those who did not.

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DENVER- Researchers at Fox Chase Cancer Center found no effects of type II diabetes on aggressiveness of prostate cancer but found that long-term survival is worse. The findings were presented today at the 47th Annual Meeting of the American Society for Therapeutic Radiology and Oncology in Denver, Colo.

disease. year relative survival rate for patients whose cancer is detected whereas still in the general and regional stages is 100%. Prostate cancer is among the foremost causes of cancer deaths in the male population in the US. The most important dilemma is that the cancer cells in prostate cancer, scarcely answer to radiotherapy or to chemotherapy. It's newly discovered that virus can help the cancer prostate treatment.

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The fear of having prostate cancer can be devastating to most men. Prostate cancer is most successfully treated when discovered early. Nearly 80 percent of all prostate cancers is discovered while they are still localized, or confined to the prostate. year survival rate for men diagnosed with prostate tumors that are discovered at this early stage is a whopping 100 percent. Testing works!

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Previous research suggests that insulin may spur the growth of prostate cancer cells. In type II diabetes, the body fails to properly use insulin, which can lead to an excessive amount of insulin in the blood.

Laboratory studies suggest that EGCG works at the cellular level to intervene against various cancers, including cancer of the breast, 33, 34 pancreas, 35 mouth, 36 colon, 37 and prostate. 38, 39 According to results from several epidemiological studies, individuals who drink green tea regularly may have less frequent or less severe cancer in various areas of the body, including the ovary, 40 prostate, 13, 41 and head and neck. 42 There is some evidence suggesting that regular intake of green tea at a level of more than three cups daily may reduce the risk of lung cancer in smokers. 43 Even more encouraging is a recent intervention study confirming the preventive effects of green tea catechins in prostate cancer. 44 Clinical trials in other types of cancer are ongoing. 1

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In the past 20 years, the survival rate for all stages of prostate cancer has risen due to early detection and treatment. Early prostate cancer often doesn t present any symptoms and can only be found with regular prostate examinations by your doctor. These tests can help detect, or rule out, prostate cancer. Check back with your physician if you have had an unusual DRE (digital rectal exam), or if your PSA ( specific antigen) level is high. Your physician may order additional tests or suggest repeating the PSA tests if warranted.

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"We looked at several key pretreatment factors used to stage the prostate cancer," explained Khanh H. Nguyen, M.D., lead author of the Fox Chase study and a resident in the radiation oncology department at Fox Chase. "These factors include the initial PSA, Gleason score and T-stage. The men with type II diabetes didn't have a significantly different initial profile for their prostate cancer than the men without diabetes. Additionally, type II diabetes did not appear to influence the rates of PSA failures or distant metastases. However, men with type II diabetes had significantly worse long-term overall survival." lap top
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The patient cohort for this study included 1,512 men with localized prostate cancer treated with radiation therapy between April 1989 and October 2001. Of these, 1,306 men had no history of type II diabetes (NDM) while 206 men had diabetes (DM-II), which was managed with diet, exercise or medications other than insulin. memory
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The study did not detect significant differences in the initial PSA, Gleason score, or T-stage between the men with and without diabetes. The median initial PSA for men with NDM was 8.2 compared to 8.7 for men with DM-II. Twenty-eight percent of NDM cases versus 26 percent of those with DM-II had a Gleason score of 7-10. By T-stage, 94 percent of NDM patients and 93 percent of DM-II patients had stage T1a-2c disease. as400
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The researchers also looked at the effect of DM-II on long-term radiation treatment outcomes. At 5 years, 27.2 percent (355) of men with NDM had PSA failures versus 23.8 percent (49) of men with DM-II. Seven percent (92) of NDM patients had distant metastases compared to 4.9 percent (10) with DM-II hardware
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. Of the patients with NDM, 3.1 percent (41) died of prostate cancer versus 2.4 percent (5) of patient with DM-II. "Although men with type II diabetes did not have significantly different treatment outcomes, having the disease had a detrimental effect on overall survival," said Nguyen. storage
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Of the men without diabetes, 19.1 percent (250) died from all causes, compared to 22.8 percent (47) deaths overall for those with DM-II. This result was statistically significant even after adjusting for the key pretreatment factors. computer sales
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Nguyen, now a radiation oncologist at the University of Tennessee Medical Center in Knoxville, Tenn., concluded, "The degree of hyperinsulinemia in type II diabetes can vary considerably and may obscure the true impact of insulin on the natural history of prostate cancer. Despite laboratory and epidemiological data suggesting an effect of insulin on prostate cancer growth, in our patient cohort, diabetes did not appear to influence the aggressiveness of prostate cancer at presentation. printers
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"However, type II diabetes conferred a significantly higher overall mortality. Aggressive management of diabetes with diet, exercise, and medications may improve the survival of cancer patients.\\\ mainframe

Fox Chase Cancer Center