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Research Gene Controlling Circadian thinkpad
Gene Controlling Circadian
Rhythms Linked to Drug Addiction
Drug Addiction Gene Updated: 6/20/2005 4:41:41 PM
Print Article Email Article The gene that
regulates the body s main biological clocks also may play a
pivotal role in drug addiction, researchers at UT Southwestern
Medical Center have found. microsoft
The Clock gene not only controls the body s circadian
rhythms, including sleep and wakefulness, body temperature,
hormone levels, blood pressure and heart activity, it may also
be a key regulator of the brain s reward system. laptop computers
UT Southwestern researchers showed that, in mice, the Clock
gene regulates the reward response to cocaine, suggesting that
similar actions take place in humans. Findings from the
multi-center study are available online in the Proceedings of
the National Academy of Sciences. laptop computer
We found that the Clock gene is not only involved in
regulating sleep/wake cycles, but is also very involved in
regulating the rewarding responses to drugs of abuse,
said Dr. Colleen A. McClung, assistant instructor of psychiatry
at UT Southwestern and the study s lead author. It
does so through its actions on dopamine pathways. desktop computer
Dopamine is a neurotransmitter associated with the
pleasure system of the brain, providing feelings of
enjoyment from certain activities. Dopamine is released by
naturally rewarding experiences such as food, sex and the use
of certain drugs. notebooks
In the study, mice that lacked the Clock gene were injected
with cocaine. Not only did the mice experience problems with
their circadian cycles - not sleeping as much and becoming more
hyperactive - they also found cocaine more rewarding than
control mice, demonstrated by their strong preference for the
location where the drug was administered. lenovo
In addition, Clock-deficient mice produced more dopamine
than control mice did, suggesting that the gene controlling
circadian rhythms is a key regulator of the brain s reward
system and may influence the addictive properties of drugs such
as cocaine. hard drive
We tracked dopamine cells in the mice brains and found
that these cells fired more rapidly and showed a pattern called
bursting, which leads to an usually large dopamine release,
Dr. McClung said. We also found that more dopamine
is produced and released in these mice under normal conditions
and particularly after exposure to cocaine. travelstar
Dr. Eric Nestler, chairman of psychiatry at UT Southwestern
and the study s senior author, said the results suggest
there may be a link in disruption of circadian rhythms and the
tendency to abuse drugs. gateway
Most work on Clock has focused on the brain s
master pacemaker, located in a brain area called the
suprachiasmatic nucleus, said Dr. Nestler. The
novelty of Dr. McClung s findings is the role Clock plays
in brain reward pathways. The next step is to examine Clock and
related genes in human addicts. laptop parts
Dr. Donald Cooper, assistant professor of psychiatry at UT
Southwestern, also contributed to the study, as did researchers
from the University of Crete in Heraklion; the Rosalind
Franklin University of Medicine and Science in North Chicago;
and the Howard Hughes Medical Institute at Northwestern
University. software
The study was supported by grants from the National
Institute on Drug Abuse, the National Institute of Mental
Health and the Onassis Public Benefit Foundation. 2005
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Sports / Exercise Health Tip Try Cross
Training repair
Health Tip: Try Cross
Training
Work different muscles by varying your routine Updated:
4/26/2007 3:26:48 PM Print Article Email
Article (HealthDay News) -- Cross training involves
varying the type of exercises you do in each workout, to work
different muscles. data recovery
For example, you might combine running and weightlifting in
one workout, and go swimming the next time. Here are some of
the benefits of cross training, courtesy of the University of
Michigan Health System: cisco
-
You ll work and condition your entire body, not just
one area. keyboard
-
You ll limit stress on one area or set of muscles,
preventing overuse injury. monitor
-
You can keep exercising -- even if you do have an injury
-- by exercising other muscles or areas. desktop
-
You ll help prevent boredom. infosys
Headaches, Pain, Arthritis
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Arthritis Health Tip Causes of
Cluster refurbished laptops
Health Tip: Causes of Cluster
Headaches
They include certain medications, and smoking Updated:
4/26/2007 3:26:48 PM Print Article Email
Article (HealthDay News) -- Cluster headaches are
severe headaches that usually cause pain behind or around one
eye. The nose may also be red, swollen or runny on the same
side as the headache. wipro
These headaches do not run in families and do not appear to
be related to other conditions, the American Academy of Family
Physicians says. The academy says the following factors may
trigger cluster headaches: lap top
-
Certain medications, including nitroglycerin. refurbished
-
Frequent smoking. memory
-
Changes in sleep schedule. intel
-
An abnormality in the hypothalamus, the part of the
brain that controls the body s biological
clock. as400
Graduate Job Search - Corporate America: Looking for a Few
Good Students
Corporate America Looking
Internship Program, Career Development Center, Kelly
Services, Business
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Dental Health Articles
Business Corporate America Looking averatec
Corporate America: Looking for a
Few Good Students
Graduate Job Search Updated: 7/26/2005 11:04:15 AM
Print Article Email Article Many recent
students are trying to figure out their next move. Some might
choose to take a few months off, while others may opt for
trying corporate America on for size. hardware
A path that many of today s students are electing to
take is expanding their knowledge outside the classroom through
internships. According to a report published by the National
Association of Colleges and Employers, college graduates who
have participated in an internship or cooperative education
assignment find themselves a step ahead of the competition in
the job market. dual xeon
It s never too late for students to secure an
internship. Many students don t know where to begin, but
resources do exist. To start, many colleges and universities
have career services and placement centers for students to
utilize. storage
Through this service, students have access to career
advisors and materials that can provide tips for writing a r
sum or preparing for an interview. Many schools also have Web
sites that allow students to browse available internship
listings. seagate
Another valuable resource exists within the career centers
of many professional associations. The Society of Manufacturing
Engineers (SME) developed its Student Zone Web page to provide
information, resources, and opportunities specifically for
those students interested in building careers within any
manufacturing industry. computer sales
The Student Zone is an extremely popular and valuable
resource for college students to gain a competitive edge as
they begin their professional careers, said Mark
Stratton, community relations manager for SME. Through
this site, students can post their r sum, browse job postings,
learn how to leverage their technical skills, and even apply
for scholarships. computer hardware
Students shouldn t rule out approaching local businesses
directly. Many corporations have job boards or dedicated Web
pages that highlight their particular internship opportunities.
It s a good market for students to secure an
internship, especially in the areas of engineering, finance,
information technology, and science. Internships are an
excellent way for students to leverage their classroom and
technical skills and to line up a potential full-time position
after graduation, said Andy Watt, senior vice president
and general manager of Kelly Services Professional,
Technical and Staffing Alternatives division. printers
Kelly Services, Inc., has recognized the need to introduce
young workers to the corporate structure before they graduate.
The global staffing company has designed and manages internship
programs for many of its clients to connect them with students,
particularly those focused on professional and technical
degrees. technology
For companies, it s a way to add support staff
during busy times of the year or to help complete special
projects. More importantly, it gives a company insight as to
what a prospective candidate is capable of and if they d be
a good fit for the company on a permanent basis, said
Watt. mainframe
monebaggasse
According to the indictment, Jones would steal various IBM and Penguin computer servers from Verisign's warehouse in Virginia and sell them to Johnson. Johnson would then sell the servers to several individuals, who would sometimes place them for sale on eBay. As a result of this scheme, the indictment alleges that Jones and Johnson caused Verisign to lose more than $120, 000 worth of computer equipment. In the indictment, Jones and Johnson are charged in three counts with causing the interstate transportation of stolen property, namely IBM 330 and 335 servers, in violation of 18 U.S.C.
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