Study identifies risk factors for multiple melanoma skin cancer

October 05, 2005 electronics

At the time, sun protection lotions were not mainstream, related risks like Melanoma and other skin cancers.

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Patients with a family history of multiple melanoma skin cancer are at increased risk of multiple primary melanomas, according to a study in the October 5 issue of JAMA.

Melanoma can be hereditary; people with family members who have had melanoma are at a higher risk for melanoma. People who have had melanoma and moles are at greater risk of developing the disease. Excessive sun exposure and sunburns increase a person's risk of developing not only melanoma but other skin cancers as well.

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Several animal and test tube studies have demonstrated an anticancer effect of polyphenols from green tea.^{10 11 12} In one of these studies, a polyphenol called catechin from green tea effectively inhibited metastasis (uncontrolled spread) of melanoma (skin cancer) cells.¹³ The polyphenols in green tea have also been associated with reduced risk of several types of cancer in humans.^{14 15 16} However, some human studies have found no association between green tea consumption and decreased cancer risk.^{17 18}

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In 2005, there will be an estimated 62,000 new cases of invasive melanoma and an estimated 7,600 deaths due to melanoma in the United States, according to background information in the article. Melanoma is the fifth leading cancer in men and the sixth leading cancer in women in the United States. The incidence of melanoma continues to rise at about 3 percent per year in the United States, with an estimated lifetime risk for an individual of 1.4 percent. This increasing incidence puts a larger portion of the population at risk not only for one primary melanoma but also for subsequent primary melanomas.

Several animal and test tube studies have demonstrated an anticancer effect of polyphenols from green tea.^{10 11 12} In one of these studies, a polyphenol called catechin from green tea effectively inhibited metastasis (uncontrolled spread) of melanoma (skin cancer) cells.¹³ The polyphenols in green tea have also been associated with reduced risk of several types of cancer in humans.^{14 15 16} However, some human studies have found no association between green tea consumption and decreased cancer risk.^{17 18}

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- Taking Care Of Your Skin Now Will Protect You Sadly, skin cancer can take 20 or more years to develop. The Skin Cancer Foundation states that most people receive about 80 percent of their lifetime sun exposure before the age of 18. Just one blistering sunburn in childhood is estimated to double the risk of melanoma later in life. Taking better care now will reduce the risk, but not eliminate the damage already done.

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Cristina R. Ferrone, M.D., and colleagues from Memorial Sloan-Kettering Cancer Center, New York, conducted a study to identify the incidence and characteristics of patients at risk of developing multiple primary melanomas (MPM). The study included 4,484 patients diagnosed with a first primary melanoma between January 1, 1996, and December 31, 2002. data recovery
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The researchers found that 385 patients (8.6 percent) had 2 or more primary melanomas, with an average of 2.3 melanomas per MPM patient. Seventy-eight percent had 2 primary melanomas. For 74 percent of patients, the initial melanoma was the thickest tumor. Fifty-nine percent presented with their second primary tumor within 1 year. Twenty-one percent of MPM patients had a positive family history of melanoma compared with only 12 percent of patients with a single primary melanoma (SPM). Thirty-eight percent of MPM patients had dysplastic nevi (DN; atypical moles) compared with 18 percent of SPM patients. keyboard
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The estimated cumulative 5-year risk of a second primary tumor for the entire cohort was 11.4 percent, with almost half of that risk occurring within the first year. For patients with a positive family history or dysplastic nevi, the estimated 5-year risk of MPM was significantly higher at 19.1 percent and 23.7 percent, respectively. The most striking increase in incidence for the MPM population was seen for development of a third primary melanoma from the time of second primary melanoma, which was 15.6 percent at 1 year and 30.9 percent at 5 years. desktop
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"Patients with a positive family history or a history of DN are at significantly greater risk of developing MPM and should be enrolled in more intensive dermatologic surveillance programs. This high-risk subset of patients should also be further characterized genetically to further elucidate the biology and etiology of melanoma," the authors conclude. refurbished laptops

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