New antibody profiling technique to test for lung cancer
November 15, 2005
Laptop Battery Biomedical scientists have revealed a new and promising antibody
profiling technique that provides a high degree of early diagnostic
accuracy for non-small cell lung cancer cases.
Both Antibody blood tests Antibody blood tests may be done to find antisperm antibodies in blood, semen, or vaginal fluids. Doctors question the value of antibody tests for finding the cause of infertility. For rmation, see the medical test Antisperm Antibody Test. Karyotype (chromosome analysis) or genetic test
Thinkpad Their research was reported in the second issue of November 2005
of the American Journal of Respiratory and Critical Care Medicine,
published by the American Thoracic Society.
This common and rapid test to identify Lyme disease antibodies is the most sensitive screening test for Lyme disease.
- Indirect fluorescent antibody (IFA).
Microsoft Li Zong, Ph.D. of the Division of Pulmonary and Critical Care
Medicine, Chandler Medical Center, University of Kentucky,
Lexington, along with five associates, has identified five
non-small cell lung cancer-associated antibody
proteins that achieved 90 percent
sensitivity and 95 percent specificity in identifying cancerous
versus non-cancerous patient samples.
- Smoking is the major cause of lung cancer; thus, most lung cancers are preventable.
- Genetics, secondhand smoke, human papillomavirus infection, an unhealthy diet, and exposure to chemicals, heavy metals, and radon gas cause lung cancer in nonsmokers.
- All these risk factors are modifiable.
- Symptoms include worsening or chronic cough, shortness of breath, wheezing, coughing up blood, back pain, and weight loss.
- Tests for lung cancer include sputum sample, ray, and computed tomography lung scanning, but a biopsy is needed for diagnosis.
- In the past 50 years, year survival rate for lung cancer has not improved significantly.
- A healthy lifestyle and diet (citrus fruits, tomatoes, spinach, carrots, cantaloupes, and sweet potatoes), in addition to supplementation with folate and vitamin B12, may help prevent lung cancer.
Laptop Computers (Sensitivity indicates the probability that results will be
positive when disease is present. Specificity identifies the
probability that results will be negative when disease is
absent.)
Antibody tests are the most commonly used tests to help identify Lyme disease and keep track of its treatment. Antibody testing may also be done on fluid from the spine or from a joint. It may take up to 2 months after becoming infected before antibodies can be detected in a blood test. Once formed, antibodies usually stay in your system for many years, even after successful treatment of the disease. Finding antibodies to the Lyme disease bacteria does not tell whether you were infected recently or sometime in the past.
Laptop Computer According to the U.S. National Cancer Institute, 160,000 people
die each year from lung cancer, making it the number one cause of
cancer death in America. Smoking is the primary cause of the
disease.
detection problem, this time specifically for lung cancer, the leading cancer killer in the United States. year survival rate for lung cancer, which is rarely detected early, is a very low 15 percent. But, if detection can be made early, survival rates of 50 percent have been seen. Researchers from Panacea Pharmaceuticals of Gaithersburg, Md., have developed a blood test that targets a protein called human aspartyl (asparaginyl) hydroxylase (HAAH), which appears on the surface of cancer cells and in the blood of people with cancer.
Desktop Computer The authors state that presently only 25 percent of new cases of
lung cancer are diagnosed at an early stage, when curative surgery
is possible.
Notebooks "Serum tumor markers have the potential of being incorporated
into diagnostic and therapeutic practice to improve historically
dismal outcomes in non-small cell lung cancer," said Dr. Zong.
"Potential uses include early detection or screening,
differentiation of benign from malignant disease, differentiating
histologies, defining stages and responses to therapy, and defining
prognosis.
Lenovo "These goals have generated considerable interest in identifying
predictive tumor markers," Dr. Zong continues. "Although a number
of non-small cell lung cancer tumor markers are measurable and a
combination of markers can enhance diagnostic
value, limited sensitivity and
specificity of these markers preclude their wide-spread clinical
use. In context, tumor-associated antigens may expand the range
of non-small cell lung cancer markers. Consistent with the
knowledge that an antibody response to a single
protein is unlikely to be a
universal marker, we have been exploring methodology for
efficiently identifying and measuring multiple tumor-associated
antibodies."
Hard Drive From a universe of 212 candidate markers, the researchers
reduced the group to the five most predictive cancer-associated
antibody proteins.
Travelstar "Results show that five phage markers had significant ability to
distinguish patient samples from normal control subjects in the
training set, said Dr. Li.
Gateway Based on their results, they hope to develop a diagnostic assay
to assist in early diagnosis of lung cancer.
Laptop Parts During development, the researchers tested the proteins
associated with predominately advanced-stage lung cancer since
those cells were theoretically more likely to express both high
levels of and a greater
variety of antibodies.
Software In subsequent studies, they plan to test persons who have
early-stage lung cancer against matched control subjects. They hope
this will help them determine the ability of antibody profiling to
distinguish benign from malignant disease in a group whose
potentially cancerous nodules cannot clearly be determined
radiographically.
Hard Drives American Thoracic Society
[ Comment, Edit or Article Submission ]
