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Plasma Zinc And Copper Levels In Healthy Thai School Children Aged 11-18 Years

Laptop Battery       Mahidol University Annual Research Abstracts 2000 155 The effect of deadspace that contains in needle removable and needle nonremovable insulin syringe on errors of insulin concentrations after dilution Aruchalean Wattanachai, Chittiwat Suprasongsin Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Marginal deficiencies of zinc result in immune function impairments.27 blind study of healthy elderly people, supplementing with 45 mg of zinc per day for one year significantly reduced the frequency of infections.28 Some doctors recommend lower amounts of supplemental zinc for people experiencing recurrent infections, such as 25 mg per day for adults and even lower amounts for children (depending on body weight). Zinc lozenges have been found helpful in some studies for the common cold. induced copper deficiency.

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Microsoft Key words : deadspace, insulin, syringe

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Even taking between 30 and 150 milligrams of zinc daily for several weeks interferes with copper absorption and can cause copper deficiency. (For this reason, doctors often recommend that those using zinc supplements take additional copper, in a ratio of 1 milligram of copper to 10 milligrams of zinc.) More than 30 milligrams of zinc a day can increase your risk of developing anemia. Such high doses have also been found to lower levels of HDL, the "good" cholesterol, while raising levels of LDL, the "bad" cholesterol. (A doctor may, however, recommend amounts this high to treat Wilson's disease, a condition involving excess copper in the body.) And increased dietary zinc has been shown to markedly decrease mental functioning in people with Alzheimer's disease. Because of these risks, doctors recommend that zinc supplements in excess of 15 milligrams a day be taken only under medical supervision.

Laptop Computer                     Volume of a solution retained in the hub and needle when the plunger of the syringe is fully depressed is defined as "dead space (DS)". This DS is a potential source of error when drugs are diluted using syringe which contains large DS. Our study was designed to assess the amount of DS and errors of insulin concentrations produced by DS comparing between two brands of needle removable insulin syringe (NRIS) and needle nonremovable insulin syringe (NNIS). The results show that DS produced by both brands of NRIS are much larger than NNIS (65.3 + 0.7, and 49.7 + 0.9 vs 2.4 + 0.1 microlitre; p<0.001) and make errors of insulin concentrations to about twice of the standard concentration (617 + 45 and 540 + 54 vs 310 microunit / ml). In summary, we demonstrate the effect of DS that contained in NRIS on insulin concentration after dilution. These higher concentrations are danger and can be a cause of hypoglycemia in diabetic patients. The effect is more pronounced in children and newborn who require low dose of insulin. Therefore we recommend to use NNIS to inject and dilute insulin instead of NRIS, especially in small children and newborn patients.

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Notebooks (The effect of deadspace that contains in needle removable and needle nonremovable insulin syringe on errors of insulin concentrations after dilution. TJN1999; 48-(3).) PLASMA ZINC AND COPPER LEVELS IN HEALTHY THAI SCHOOL CHILDREN AGED 11-18 YEARS FROM BANGKOK Sriwatana Songchitsomboon1, Umaporn Suthutvoravut2, Somsri Charoenkiatkul3. 1Research center, 2Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital and 3Institute of Nutrition, Mahidol University, Bangkok 10400, Thailand.

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Gateway                     The purpose of this study was to establish the reference values of plasma zinc (Zn) and copper (Cu) in Thai children. Plasma Zn and Cu were measured in 201 healthy school children (108 males, 93 females), aged 11-18 years, studying in Bangkok. All subjects without chronic diseases or using of supplementary vitamins or minerals, had normal weight-for-age and height-for-age according to the US National Center for Health Statistics (NCHS) reference. Plasma Zn and Cu were determined by flame atomic absorption spectrophotometry. Calibration curves were prepared by using standard

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