Mahidol University Annual Research Abstracts
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Limits Muscle Growth! Block It! Myostatin is a protein that regulates how much muscle mass is produced. If the gene that encodes myostatin is hindered, mutated or blocked, studies show more muscle mass is developed. Studies done on mice show that when their gene was "knocked out" they developed two to three times more muscle than mice that had the gene still intact. One researcher said they "look like Schwarzenegger mice."
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In 1999, density microarrays, or gene chips. Drs. Richard Weindruch and Tomas Prolla of the University of Wisconsin published a study of gene expression in the muscles of both normal and CR mice. 5 Gene chips enabled the scientists to rapidly measure changes in the expression of more than 6, 000 genes. Not only was this a dramatic shortcut to finding genes involved in extending maximum life span, but it also provided an approach to screening for CR mimetics.
Microsoft Institute of Science and Technology for Research and Development
The findings on the gene, called Brahma (BRM), are published online in the journal Oncogene. Genetic mutations are one cause of cancer. But the disease can also develop when genes that control cell growth are turned off, allowing cells to multiply out of control. Currently, these deactivated genes can be used to identify or monitor cancer, but there are no treatments that actually target these genes, according to background information in the study.
Laptop Computers sleep breathing disturbances, oxygen desaturation, periodic arousal and limb movements, and alterations of heart rate and blood pressure. There were significant differences between the two groups with respect to respiratory behaviours and associated episode of oxygen desaturation during sleep. Relatives of SUNDS victims had significantly more frequent and longer periods of sleep hypopnea and apnea than the control group. The hypopnea and apnea episodes (ranging from 20 to 180 seconds in duration) were usually characterized by asynchronous thoracoabdominal movements accompanied by prolonged inspiration, followed by reduction or cessation of movements, predominantly of the central or mixed type of apnea which were accompanied by gradual oxygen desaturation. The hypoxic episodes in these subjects were terminated by a brief period of arousal and resumption of breathing which corrected and returned the oxygen saturation to normal levels. These episodes occurred repetitively during the first cycle of Non-Rapid Eye-Movement (Non-REM) sleep and more frequently during successive cycles of REM-sleep, especially during the early morning where the highest incidence of death have been reported among SUNDS victims. The computer-analyzed indexes of hypopnea and apnea were also significantly higher in the SUNDS relatives group than among controls. The present evidence suggests that abnormalities in the control of breathing during sleep and/or mechanisms of compensatory arousal from hypoxia during prolonged sleep apnea may be an important element or factor in the chain of events leading to sudden cardiopulmonary arrest and death in SUNDS.
scale study carried out in Queensland, Australia, the deciding factor on acne severity is in your genes, not the environment.
Laptop Computer (Supported in part by Research Grants from Mahidol University and the Department of Medical Services, Ministry of Public Health of Thailand.)
In other studies, Dr. Spindler has explored the effects of aging and caloric restriction on certain stress genes. One of the things he's found in old age is that stress gene expression seems to increase to a higher level, but that caloric restriction decreases this type of expression. Dr. Spindler's studies suggest that lower levels of stress gene expression may be related to less damage to the kidney and blood vessels during aging.
Desktop Computer Current Claim: The present evidence suggests that abnormalities in the control of breathing during sleep and/or mechanisms of compensatory arousal from hypoxia during prolonged sleep apnea may be an important element or factor in the chain of events leading to sudden cardiopulmonary arrest and death in SUNDS.
Notebooks (Presented at the 3rd International Congress of the Asian Sleep Research Society on the New Millennium of Sleep Research in Asia, December 3-7, 2000, Bangkok, Thailand, and published in the Program and Abstracts page A170.)
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Travelstar SUDDEN UNEXPLAINED NOCTURNAL DEATH SYNDROME (SUNDS OR LAI
TAI): A STUDY OF THE MONOAMINE OXIDASE-A GENE BY GENE
AMPLIFICATION WITH THE POLYMERASE CHAIN REACTION (PCR). (NO. 935)
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Laptop Parts Somporn Triamchaisri1,2, Naiphinich Kotchabhakdi1, Stefano O. Casalotti1, Prapon Wilairat3, Daorung Kangwarnpong4 and Songsak Petmitr5.
Software 1Neuro-Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University, Salaya, Nakornpathom 73170 Thailand; 2 Faculty of Public Health; 3 Department of Biochemistry, Faculty of Science; 4 Department of Pathology, Faculty of Medicine at Ramathibodi Hospital;
5 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Hard Drives Key words: Sudden Unexplained Nocturnal Death Syndrome (SUNDS), Lai Tai, Monoamine oxidase A (MAO-A), X-chromosome, MAO-A gene, PCR.
Electronics Our previous studies ( Kotchabhakdi, N.: Japanese Journal of Psychiatry and Neurology 48,135-137,1994 ) have proposed and established that the cause of death among the victims of Sudden Unexplained Nocturnal Death Syndrome ( SUNDS or Lai Tai ) might involve a genetically inherited predisposing factor related to gene loci on the human X-chromosome. One of the candidate genes which could be functionally related to brainstem neuronal mechanisms controlling respiration during sleep is the gene for the monoamine oxidase-A (MAO-A), an important enzyme in the brain which catalyzes the oxidative degradation of monoamine neurotransmitters such as norepinephrine, dopamine, serotonin and histamine. The MAO-A gene (located at the position Xp11.23 - 11.4 ) is comprised of 15 exons and 14 introns spanning at least 70 kilobases and has a full length coding sequence of 1.6 Kb in human. The MAO-A gene is normally expressed at relatively high levels in catecholaminergic neurons in the brainstem. In this study, Deoxyribonucleic acids (DNAs) were extracted from white blood cells of the living parent and 4 siblings of an autopsy-verified SUNDS victim. In addition, DNAs were also extracted from tissues of another 9 autopsy-verified SUNDS victims and two normal males. The integrity of the MAO-A gene in all cases was probed by the method of gene amplification with polymerase chain reaction (PCR) using 5 primers for MAO-A gene exons 3, 4 , 5-6, 14-15, and exon 2 of K-ras gene for the positive control. In 2 cases of SUNDS victims, there was a deletion of exon 4 through 15; in one case, the deletion was from exon 5 to 15. In another 6 cases, the deletion was from exon 3 to 15 and a similar deletion was also found in the two living brothers of a SUNDS victim from our previous pedigree study, while in the father and sister of the same victim the MAO-A gene appeared to be normal. In the victims mother, the MAO-A gene can be amplified but at a significantly decreased level ( a light band ). Although the discovery needs to be replicated on a much larger scale, the present evidence from the gene amplification study is consistent with the previous pedigree study, and confirms the proposed hypothesis that SUNDS may involve a genetically inherited predisposition which is transmitted by the X-linked recessive model. Furthermore, the discovery has an important potential for the development of massive screening and logical intervention for high risk individuals through a specific gene marker and gene therapy.
Canon (Supported in part by Research Grants from Mahidol University and the Department of Medical Services, Ministry of Public Health of Thailand.)
Desktop Pc Current Claim: Sudden Unexplained Nocturnal Death Syndrome (SUNDS, or Lai Tai) may involve a genetically inherited predisposition, which is transmitted by the X-linked recessive model related to mutation of mono amine oxidase A gene.
Desktop Computers (Presented at the 3rd International Congress of the Asian Sleep Research Society on the New Millennium of Sleep Research in Asia, December 3-7, 2000, Bangkok, Thailand, and published in the Program and Abstracts page A171.)
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Data Recovery DISTRIBUTION OF ENZYMES MONOAMINE OXIDASE IN THE BRAINSTEM OF
THE VICTIMS OF SUDDEN UNEXPLAINED NOC-TURNAL DEATH SYNDROME
(SUNDS) AS COMPARED TO THE NORMAL ADULT THAI MALES. (NO. 936)
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Keyboard Naiphinich Kotchabhakdi1, Wacharin Onla-iad1, 3, Piyarat Govitrapong1, Somporn Triamchaisri2, and Suchart Phudhichareonrat3.
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