John Burke, professor of microbiology and molecular genetics and a University Scholar for the current year, will discuss The New Biology of RNA in a University Scholar Seminar on Sept. 28 at 4 p.m. in Memorial Lounge, Waterman Building. Refreshments will precede and follow Burkes talk.
Long thought to be a molecule whose sole function is to convey genetic information, RNA is now known to possess a wider range of biological functions than either of its macromolecular counterparts, DNA and protein. RNA catalyzes ubiquitous biochemical reactions, including ribosomal protein synthesis and tRNA biogenesis. In addition, RNA mediates a wide range of RNA processing reactions that are critical for gene expression and the replication of viruses.
Burkes research lab has focused on understanding the catalytic properties of RNA molecules. This work has led to new insights into RNA biology, particularly the structure and catalytic mechanisms of RNA enzymes (ribozymes). In addition to furthering understanding of biological molecules and their reactions, RNA research has potential for practical uses, especially the control of viral and genetic diseases.
Burkes discoveries have been reported in outstanding journals, among them Cell, Nature, Genes and Development, EMBO Journal and the Proceedings of the National Academy of Sciences, in addition to which he has been invited to present at nearly 150 universities and conferences around the world. Burkes work has received significant and consistent support from the National Institutes of Health; he is currently the principal investigator on three NIH awards.
Also a sought-after research mentor, Burke is known as an outstanding teacher by undergraduate, graduate and medical students. He has graduated seven doctoral students, currently supervises five doctoral candidates, and has trained numerous post-doctoral researchers. His students and post-docs have gone on to faculty positions and top jobs in industry. Burkes professional service includes editorial boards and manuscript review for a number of journals, chairing numerous conference sessions, grant review for agencies including NIH, NSH, ACS and Research Corporation.
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